Ub-VS：a potent and specific inhibitor of deubiquitinating enzymes (DUBs)。一種有效的特異性去泛素化酶 （DUB） 抑制劑。
code: UbiQ-108
category: activity-based probes
applications:
crystallization, purification, western blot, phenotypic protein profiling, dub activity profiling
英文描述：
Ubiquitin-Viny Sulfone (UbiQ-108) is a potent and specific inhibitor of deubiquitinating enzymes (DUBs). This activity probe can be used for activity profiling experiments and determining DUB inhibitor specificity. It targets all two of the major DUB families: USP and OTU.
中文描述：
Ubiquitin-Viny Sulfone （UbiQ-108） 是一種有效的特異性去泛素化酶 （DUB） 抑制劑。該活性探針可用于活性分析實驗和確定 DUB 抑制劑特異性。它針對所有兩個主要的 DUB 系列：USP 和 OTU。
產品文獻：
1.Galardy, P., et al. Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: crystallography, activity profiling, and protease identification. Methods in Enzymology. 399, 120-131 (2005).
ncbi.nlm.nih.gov/pubmed/16338352
2. de Jong, A., et al. Ubiquitin-based probes prepared by total synthesis to profile the activity of deubiquitinating enzymes. ChemBiochem 13, 2251-2258 (2012).
ncbi.nlm.nih.gov/pubmed/23011887
3. Wrigley, J.D. et al. Enzymatic characterisation of USP7 deubiquitinating activity and inhibition. Cell Biochem. Biophys. 60, 99-111 (2011)
ncbi.nlm.nih.gov/pubmed/21468692
